Production of Polycaprolactone/Hidroxyapatite Scaffold for Application in Tissue Engineering

Joanne G. A. Mendes; João Pedro de A. Caribé; Adillys M. da C. Santos; Willams T. Barbosa; Josiane D. V. Barbosa; Luis Alberto Loureiro dos Santos; Liciane Sabadin Bertol; Imarally V. de S.R. Nascimento

doi:10.34178/jbth.v6i4.320

Joanne G. A. Mendes
João Pedro de A. Caribé
Adillys M. da C. Santos
Willams T. Barbosa
Josiane D. V. Barbosa
Luis Alberto Loureiro dos Santos
Liciane Sabadin Bertol
Imarally V. de S.R. Nascimento

DOI: https://doi.org/10.34178/jbth.v6i4.320

Keywords: Tissue Engineering, Composites, Scaffolds

Abstract

The study aims to produce fibrous polycaprolactone (PCL) scaffolds with hydroxyapatite (HA) incorporation using the Solution Blown Spinning (SBS) technique for application in tissue engineering. The scaffolds were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), contact angle, and thermogravimetric analysis (TG). The images obtained by SEM showed that the fibers have a diameter on a micrometer scale. FTIR spectra indicated physical and chemical interactions between PCL and HA. TG analysis showed the presence of HA, which provided an anticipation of the PCL degradation temperature. We obtained micrometric fibers of PCL and PCL/HA with different orientations. The technique used is promising for making scaffolds.