Clinical Trials for COVID-19 – An Urgent Response

Abstract

In this article, we listed databases, guidance, protocols, guidelines, and similar resources that have been produced to help in the tracking and identification of trials and studies about COVID-19. We focused the clinical trials with antiviral drugs, inflammatory cascade (cytokine storm) / target-receptors / blokers, antibiotics, complement system, antibodies, breathing support, testing methods, healthcare workers, impact on other conditions, and vaccines. We used four database to reproduce the clinical trials and to present some of the most promising therapeutic approaches from March to May, 2020: clinicaltrials.gov (clincial trials around the word and in the USA – 1,833 clinical trials in May 30, 2020), the data from Brazil (Rebec), EU Clinical Trials Register (European Union – 37,503 clinical trials with a EudraCT protocol), and the list of the International Clinical Trials Registry Platform (ICTRP) from World Health Organization (WHO). We also prepared an Appendix with the main promise clinical trials evidences against COVID-19 until May 10, 2020.